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Bhr2A/J
QTL Variant Detail
Summary
QTL variant: Bhr2A/J
Name: bronchial hyperresponsiveness 2; A/J
MGI ID: MGI:2389414
QTL: Bhr2  Location: Chr15:64306334-103425899 bp  Genetic Position: Chr15, cM position of peak correlated region/allele: 29.03 cM
QTL Note: genome coordinates based on the boundaries of the QTL region
Variant
origin
Strain of Specimen:  A/J
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:29231

Airway hyperresponsiveness in mice is inherited as a polygenic trait in C57BL/6J and A/J mice. The asthma-like phenotype in A/J mice is expressed differently then the phenotype expressed in C57BL/6J mice, therefore allowing for the quantitative mapping (QTL) of this trait in (C57BL/6J x A/J)F1 x C57BL/6J backcross mice. A genome wide scan using Mit markers indicated that one such locus, Bhr2, mapped to mouse Chromosome 15 between D15Mit122 and D15Mit35 with a LOD score of 3.7.

Bhr3 interacts with Bhr1 and Bhr2. Homozygosity for C57BL/6J-derived alleles at either Bhr1 or Bhr3 confers simlilar decrease in airway hyperresponsiveness as homozygosity at both Bhr1 and Bhr3.

Heterozygosity at either Bhr2 or Bhr3 confers similar increase in airway hyperresponsiveness as heterozygosity at both Bhr2 and Bhr3.

References
Original:  J:29231 De Sanctis GT, et al., Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet. 1995 Oct;11(2):150-4
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory