Bhr2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bhr2^C57BL/6J
• Name: bronchial hyperresponsiveness 2; C57BL/6J
• MGI ID: MGI:2389415
• QTL: Bhr2 Location: Chr15:64306334-103425899 bp Genetic Position: Chr15, cM position of peak correlated region/allele: 29.03 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Heterozygosity at either Bhr2 or Bhr3 confers similar increase in airway hyperresponsiveness as heterozygosity at both Bhr2 and Bhr3.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:29231

Airway hyperresponsiveness in mice is inherited as a polygenic trait in C57BL/6J and A/J mice. The asthma-like phenotype in A/J mice is expressed differently then the phenotype expressed in C57BL/6J mice, therefore allowing for the quantitative mapping (QTL) of this trait in (C57BL/6J x A/J)F1 x C57BL/6J backcross mice. A genome wide scan using Mit markers indicated that one such locus, Bhr2, mapped to mouse Chromosome 15 between D15Mit122 and D15Mit35 with a LOD score of 3.7.

Bhr3 interacts with Bhr1 and Bhr2. Homozygosity for C57BL/6J-derived alleles at either Bhr1 or Bhr3 confers simlilar decrease in airway hyperresponsiveness as homozygosity at both Bhr1 and Bhr3.

Heterozygosity at either Bhr2 or Bhr3 confers similar increase in airway hyperresponsiveness as heterozygosity at both Bhr2 and Bhr3.

References

• Original: J:29231 De Sanctis GT, et al., Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet. 1995 Oct;11(2):150-4
• All: 1 reference(s)