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Bmd4C57BL/6J
QTL Variant Detail
Summary
QTL variant: Bmd4C57BL/6J
Name: bone mineral density 4; C57BL/6J
MGI ID: MGI:2389417
QTL: Bmd4  Location: Chr15:56186708-103425899 bp  Genetic Position: Chr15, cM position of peak correlated region/allele: 22.92 cM
QTL Note: genome coordinates based on the boundaries of the QTL region
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:58152

Bone mineral density (Bmd4) was measured as a quantitative trait (QTL) in a genome wide scan of 711 F2 mice in a genetic intercross involving C57BL/6J and CAST/Ei mice. C57BL/6J females express a low mineral bone density phenotype, alternatively CAST/Ei male express a high mineral bone density. Regression analysis was informative to show Bmp4 significantly associated with marker D15Mit29 within a defined QTL region bounded by markers D15Mit115 and D15Mit35. Due to the large size of the QTL region the authors did not suggest any candidate loci encoding for the Bone mineral density phenotype.

References
Original:  J:58152 Beamer WG, et al., Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. Mamm Genome. 1999 Nov;10(11):1043-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory