Smad2^tm1Kato
Targeted Allele Detail

Summary

• Symbol: Smad2^tm1Kato
• Name: SMAD family member 2; targeted mutation 1, Mitsuyasu Kato
• MGI ID: MGI:2389478
• Gene: Smad2 Location: Chr18:76374651-76444034 bp, + strand Genetic Position: Chr18, 51.42 cM
• Alliance: Smad2^tm1Kato page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79668
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were replaced with a floxed neomycin selection cassette inserted by homologous recombination. (J:79668)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad2 Mutation: 52 strains or lines available

References

• Original: J:79668 Hamamoto T, et al., Compound disruption of smad2 accelerates malignant progression of intestinal tumors in apc knockout mice. Cancer Res. 2002 Oct 15;62(20):5955-61
• All: 1 reference(s)