Mt3^tm1Rpa
Targeted Allele Detail

Summary

• Symbol: Mt3^tm1Rpa
• Name: metallothionein 3; targeted mutation 1, Richard D Palmiter
• MGI ID: MGI:2389488
• Synonyms: Mt3^-
• Gene: Mt3 Location: Chr8:94879235-94880774 bp, + strand Genetic Position: Chr8, 46.29 cM
• Alliance: Mt3^tm1Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38222
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 2.2 kb of sequence, encompassing the promoter and exons 1 and 2, was replaced by a neomycin selection cassette. Quantitative solution hybridization showed an absence of transcript in samples derived from homozygous mutant mice. (J:38222)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mt3 Mutation: 5 strains or lines available

References

• Original: J:38222 Erickson JC, et al., Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures. J Neurosci. 1997 Feb 15;17(4):1271-81
• All: 14 reference(s)