Cyp19a1^tm1Sih
Targeted Allele Detail

Summary

• Symbol: Cyp19a1^tm1Sih
• Name: cytochrome P450, family 19, subfamily a, polypeptide 1; targeted mutation 1, Shin-ichiro Honda
• MGI ID: MGI:2389548
• Synonyms: ArKO
• Gene: Cyp19a1 Location: Chr9:54073221-54175394 bp, - strand Genetic Position: Chr9, 29.49 cM
• Alliance: Cyp19a1^tm1Sih page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51076
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing the proximal promoter and exons 1 and 2 was replaced by a neomycin selection inserted by homologous recombination. The deleted region included transcriptional and translational start sites and encoded amino acids essential for transmembrane topology. RT-PCR analysis of ovary and brain tissue indicated an absence of transcript in homozygous mutant mice. (J:51076)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp19a1 Mutation: 39 strains or lines available

References

• Original: J:51076 Honda S, et al., Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene. Biochem Biophys Res Commun. 1998 Nov 18;252(2):445-9
• All: 28 reference(s)