Adgrv1^frings
Spontaneous Allele Detail

Summary

• Symbol: Adgrv1^frings
• Name: adhesion G protein-coupled receptor V1; frings
• MGI ID: MGI:2389570
• Synonyms: frings, Mass1^frings
• Gene: Adgrv1 Location: Chr13:81243187-81781273 bp, - strand Genetic Position: Chr13, 42.18 cM
• Alliance: Adgrv1^frings page

Mutation origin

• Strain of Origin: various

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: The phenotype of the Frings mouse has been attributed to a single nucleotide deletion (guanine 7009) that results in a nonsense mutation in exon 27 (codon 2072). The stop codon putatively precludes translation of a multicopper oxidase (MCOI) consensus site in all three splice variants. The allele was originally described in RB/1 strain, but subsequently the same mutation was found in BUB/BnJ strain but not in 11 other strains of Swiss albino mice. (J:71344)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adgrv1 Mutation: 318 strains or lines available

References

• Original: J:25341 Frings H, et al., The production of stocks of albino mice with predictable susceptibilities to audiogenic seizures. Behaviour. 1953;5(1):305-19
• All: 12 reference(s)