Tg(Hsp70-1-cre)6Arge
Transgene Detail

Summary

• Symbol: Tg(Hsp70-1-cre)6Arge
• Name: transgene insertion 6, Argiris Efstratiadis
• MGI ID: MGI:2389573
• Synonyms: Hs-cre6, Hspa1b-cre6
• Transgene: Tg(Hsp70-1-cre)6Arge Location: unknown
• Alliance: Tg(Hsp70-1-cre)6Arge page

Transgene origin

• Strain of Origin: C57BL/6J x CBA

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Hsp70-1-cre)6Arge expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hspa1b (MGI:99517)

• Mutation details: A sequence fragment from the murine Hsp70-1 locus encompassing 655 bp of the 5' flanking and noncoding sequence was adjoined to sequence encoding cre recombinase. A single integration of the transgenic construct was identified in the founder line. Graded expression of the transgenic construct (determined by a range of 0% to 100% recombination of reporter loci) was observed in non heat shock induced embryos. Additionally, heat shock induces expression. (J:60711)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hspa1b (mouse) Summary of all recombinase alleles driven by Hspa1b. Comparative matrix view of recombinase activities Alliance mouse Hspa1b gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:60711 Dietrich P, et al., Conditional mutagenesis in mice with heat shock promoter-driven cre transgenes. Mamm Genome. 2000 Mar;11(3):196-205
• All: 8 reference(s)