Tyk2^tm1Shmd
Targeted Allele Detail

Summary

• Symbol: Tyk2^tm1Shmd
• Name: tyrosine kinase 2; targeted mutation 1, Kazuya Shimoda
• MGI ID: MGI:2389582
• Synonyms: Tyk2-
• Gene: Tyk2 Location: Chr9:21015364-21042539 bp, - strand Genetic Position: Chr9, 7.71 cM, cytoband A3
• Alliance: Tyk2^tm1Shmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65409
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette inserted by homologous recombination replaced the first coding exon of the endogenous locus. Protein was undetected by immunoprecipitation and Western blot analysis spleen lysates obtained from homozygous mutant mice. (J:65409)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tyk2 Mutation: 72 strains or lines available

References

• Original: J:65409 Shimoda K, et al., Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Immunity. 2000 Oct;13(4):561-71
• All: 25 reference(s)