Dst^tm1Efu
Targeted Allele Detail

Summary

• Symbol: Dst^tm1Efu
• Name: dystonin; targeted mutation 1, Elaine Fuchs
• MGI ID: MGI:2429314
• Synonyms: BPAG1 null
• Gene: Dst Location: Chr1:33947306-34347742 bp, + strand Genetic Position: Chr1, 12.91 cM
• Alliance: Dst^tm1Efu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24974
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 4.7 kb of sequence encompassing the start codon, exons 1 through 3, and a portion of exon 4 was replaced by a neomycin selection cassette inserted by homologous recombination. Northern and Western blot analysis of skin tissue obtained from homozygous mutant mice indicated an absence of transcript and protein. (J:24974)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dst Mutation: 557 strains or lines available

References

• Original: J:24974 Guo L, et al., Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Cell. 1995 Apr 21;81(2):233-43
• All: 6 reference(s)