Socs6^tm1Dlk
Targeted Allele Detail

Summary

• Symbol: Socs6^tm1Dlk
• Name: suppressor of cytokine signaling 6; targeted mutation 1, Danielle L Krebs
• MGI ID: MGI:2429394
• Synonyms: SOCS-6 -
• Gene: Socs6 Location: Chr18:88883293-88912623 bp, - strand Genetic Position: Chr18, 58.66 cM
• Alliance: Socs6^tm1Dlk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77039
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Disruption caused by insertion of vector
• Mutation details: The entire open reading frame was replaced with a cassette containing lacZ and neo inserted at the enodgenous start codon by homologous recombination. Neither transcript nor protein was undetected by Northern or Western blot analyses of a variety of tissues obtained from homozygous mutant mice. Expression of beta-galactosidase was driven by the endogenous promoter. (J:77039)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Socs6 Mutation: 14 strains or lines available

References

• Original: J:77039 Krebs DL, et al., SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol Cell Biol. 2002 Jul;22(13):4567-78
• All: 2 reference(s)