Tg(Igh-HOX11)11Idd
Transgene Detail

Summary

• Symbol: Tg(Igh-HOX11)11Idd
• Name: transgene insertion 11, Ian Dube
• MGI ID: MGI:2429404
• Synonyms: IgHmu-HOX11^Tg
• Transgene: Tg(Igh-HOX11)11Idd Location: unknown
• Alliance: Tg(Igh-HOX11)11Idd page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-HOX11)11Idd expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TLX1 (3195)

  Tlx1	(MGI:98769)

• Mutation details: Human HOX11 cDNA was placed under the control of the murine Igh-V region promoter fused to the IgH enhancer. Expression of HOX11 was detected in the kidney via Northern blot analysis and in bone marrow and speen tissue via RNAse protection. Founder mice carried between 2 and 4 copies of the transgenic construct. (J:52782)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:52782 Hough MR, et al., A model for spontaneous B-lineage lymphomas in IgHmu-HOX11 transgenic mice. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13853-8
• All: 4 reference(s)