Tg(MMTV-TGFBR2)7Hlm
Transgene Detail
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Symbol: |
Tg(MMTV-TGFBR2)7Hlm |
Name: |
transgene insertion 7, Harold L Moses |
MGI ID: |
MGI:2429406 |
Synonyms: |
MMTV-DNIIR-7, TGF-betaRIIDN |
Transgene: |
Tg(MMTV-TGFBR2)7Hlm Location: unknown
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Alliance: |
Tg(MMTV-TGFBR2)7Hlm page
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Strain of Origin: |
(C57BL/6 x DBA)F2
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(MMTV-TGFBR2)7Hlm expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
TGFB2 (7042) |
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Mutation details: A human cDNA encoding a carboxy-terminally truncated TGFBR2 was adjoined to an MMTV regulatory region. While the encoded receptor contains the complete extracellular and transmembrane domains and is therefore capable of ligand binding and and interacting with type 1 receptors, it lacks the kinase domain. Expression was driven in mammary epithelial cells by the MMTV LTR promoter/enhancer. Transgenic expression was verified by Northern blot analysis.
(J:46432)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:46432 Gorska AE, et al., Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice. Cell Growth Differ. 1998 Mar;9(3):229-38 |
All: |
5 reference(s) |
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