Tg(KRT5-Tert)8043Blas
Transgene Detail

Summary

• Symbol: Tg(KRT5-Tert)8043Blas
• Name: transgene insertion 8043, Maria A Blasco
• MGI ID: MGI:2429416
• Synonyms: K5-mTert, K5-mTERT (T1), K5-Tert, tgTert
• Transgene: Tg(KRT5-Tert)8043Blas Location: unknown
• Alliance: Tg(KRT5-Tert)8043Blas page

Transgene origin

• Strain of Origin: C57BL/6 x DBA/2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-Tert)8043Blas expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tert (MGI:1202709)

• Tg(KRT5-Tert)8043Blas expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: The transgenic construct contained full length murine Tert cDNA adjoined to the bovine KRT5 regulatory region, active in basal keratinocytes. Upregulation of telomerase activity was observed in stratified epithelia of uterus, trachea, and skin tissue obtained from transgenic mice. (J:69757)

Tumor Data

List all tumor models in MMHCdb carrying Tg(KRT5-Tert)8043Blas

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:69757 Gonzalez-Suarez E, et al., Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J. 2001 Jun 1;20(11):2619-30
• All: 10 reference(s)