Igk^tm1Dhu
Targeted Allele Detail

Summary

• Symbol: Igk^tm1Dhu
• Name: immunoglobulin kappa chain complex; targeted mutation 1, Dennis Huszar
• MGI ID: MGI:2429510
• Synonyms: Ckappa-, JH^-, kappa^-
• Gene: Igk Location: Chr6:67532620-70703738 bp, + strand Genetic Position: Chr6, 30.89 cM, cytoband F1-pter

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:4128
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A neomycin resistance gene cassette replaced sequence encompassing all 5 segments of the Igk-J region, the Igk intronic enhancer (Ekappa or Rr158), and Igk-C. (J:4128)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igk Mutation: 26 strains or lines available

References

• Original: J:4128 Chen J, et al., B cell development in mice that lack one or both immunoglobulin kappa light chain genes. EMBO J. 1993 Mar;12(3):821-30
• All: 52 reference(s)