M6pr^tm1Psa
Targeted Allele Detail

Summary

• Symbol: M6pr^tm1Psa
• Name: mannose-6-phosphate receptor, cation dependent; targeted mutation 1, Paul Saftig
• MGI ID: MGI:2429535
• Synonyms: MPR46 -
• Gene: M6pr Location: Chr6:122285679-122294639 bp, + strand Genetic Position: Chr6, 57.52 cM
• Alliance: M6pr^tm1Psa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:16151
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 3 was disrupted by the insertion of a neomycin selection cassette. Expression was undetected by Northern and Western blot analysis various tissues obtained from homozygous mutant mice. (J:16151)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any M6pr Mutation: 27 strains or lines available

References

• Original: J:16151 Koster A, et al., Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in misrouting of lysosomal proteins. EMBO J. 1993 Dec 15;12(13):5219-23
• All: 8 reference(s)