Rapop5^C3H/Kam
QTL Variant Detail

Summary

• QTL variant: Rapop5^C3H/Kam
• Name: radiation-induced apoptosis 5; C3H/Kam
• MGI ID: MGI:2429536
• QTL: Rapop5 Location: Chr15:9273022-79474762 bp Genetic Position: Chr15, cM position of peak correlated region/allele: 19.26 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/Kam

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68174

A genome wide scan was performed using female animals from a (C57BL/6J x C3Hf/Kam)F2 cross to uncover loci involved in radiation-induced apoptosis of jejunal crypt cells. 159 markers at an average spacing spacing of 10 cM were used in the genome scan. Rapop5, a QTL involved in radiation-induced apoptosis of jejunal cells, mapped to mouse Chromosome 15 with a peak LOD score of 3.35 between markers D15Mit100 and D15Mit17. C57BL/6J animals show higher levels of cellular apoptosis compared to C3Hf/Kam animals, either with or without exposure to low-dose radiation. In addition, seven different strains carrying recombinations in Chromosome 15 were constructed by a series of (C57BL/6J x C3Hf/Kam) x C3Hf/Kam backcrosses to confirm and localize Rapop5. Rapop5 wasconfirmed and localized to a region on Chromosome 15 between markers D15Mit175 and D15Mit71 . Four QTLs influencing radiation-induced apoptosis in thymus cells, Rapop1 (chromosome 16), Rapop2 (Chromosome 9), Rapop3 (Chromosome 3), and Rapop4 (Chromosome 11), were previously mapped using the same cross.

References

• Original: J:68174 Weil MM, et al., A chromosome 15 quantitative trait locus controls levels of radiation-induced jejunal crypt cell apoptosis in mice. Genomics. 2001 Feb 15;72(1):73-7
• All: 1 reference(s)