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Mostm1Sia
Targeted Allele Detail
Summary
Symbol: Mostm1Sia
Name: Moloney sarcoma oncogene; targeted mutation 1, Shinichi Aizawa
MGI ID: MGI:2429547
Gene: Mos  Location: Chr4:3870658-3872105 bp, - strand  Genetic Position: Chr4, 2.16 cM, cytoband A1-A2
Alliance: Mostm1Sia page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:19086
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe endogenous allele was disrupted by the insertion of a PGK-neo cassette into sequences encoding kinase domain 5. RNAse protection showed a 214 bp 5' fragment as well as a 3' fragment expressed from the PGK promoter. Stop codons in the neo cassette preclude the translation of 3' kinase domains. (J:19086)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mos Mutation:  21 strains or lines available
References
Original:  J:19086 Hashimoto N, et al., Parthenogenetic activation of oocytes in c-mos-deficient mice [see comments] [published erratum appears in Nature 1994 Aug 4;370(6488):391]. Nature. 1994 Jul 7;370(6484):68-71
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory