Mos^tm1Sia
Targeted Allele Detail

Summary

• Symbol: Mos^tm1Sia
• Name: Moloney sarcoma oncogene; targeted mutation 1, Shinichi Aizawa
• MGI ID: MGI:2429547
• Gene: Mos Location: Chr4:3870658-3872105 bp, - strand Genetic Position: Chr4, 2.16 cM, cytoband A1-A2
• Alliance: Mos^tm1Sia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19086
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The endogenous allele was disrupted by the insertion of a PGK-neo cassette into sequences encoding kinase domain 5. RNAse protection showed a 214 bp 5' fragment as well as a 3' fragment expressed from the PGK promoter. Stop codons in the neo cassette preclude the translation of 3' kinase domains. (J:19086)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mos Mutation: 21 strains or lines available

References

• Original: J:19086 Hashimoto N, et al., Parthenogenetic activation of oocytes in c-mos-deficient mice [see comments] [published erratum appears in Nature 1994 Aug 4;370(6488):391]. Nature. 1994 Jul 7;370(6484):68-71
• All: 2 reference(s)