Aod1^A/J
QTL Variant Detail

Summary

• QTL variant: Aod1^A/J
• Name: autoimmune ovarian dysgenesis 1; A/J
• MGI ID: MGI:2429551
• QTL: Aod1 Location: Chr16:32130840-32523112 bp Genetic Position: Chr16, cM position of peak correlated region/allele: 22.55 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL

Notes

Interaction between Aod4 and Aod1 appears to influence oophoritis severity and ovarian dystrophy.

Interaction between Aod3 and Aod1 appears to affect the oophoritis phenotype.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:25722

D3Tx, A/J and (D3Tx x A/J)F1 mice are susceptible to AOD (autoimmunne ovarian dysgenesis disease) whereas C57BL/6J mice are resistant thus allowing for the potenial to genetically map the disease within these strains. One hundred and forty-four D3Tx x (C57BL/6J x A/J)F1 x C57BL/6J backcross mice were generated. Based on chi square analysis significant linkage of AOD (gene symbol Aod1) with Chromsome 16 markers D16Mit58 (p = 0.00086) and D16Mit60 (p = 0.00086) was indicated. AOD is distinguished by 2 phenotypes, presence of anti-ovarian antibodies and oophoritis, which when analyzed independently also segregated with markers on Chromsome 16.

References

• Original: J:25722 Wardell BB, et al., Aod1, the immunoregulatory locus controlling abrogation of tolerance in neonatal thymectomy-induced autoimmune ovarian dysgenesis, maps to mouse chromosome 16. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4758-62
• All: 2 reference(s)