Bbaa19^C3H/HeN
QTL Variant Detail

Summary

• QTL variant: Bbaa19^C3H/HeN
• Name: B.burgdorferi-associated arthritis 19; C3H/HeN
• MGI ID: MGI:2429556
• QTL: Bbaa19 Location: Chr16:13066828-13066977 bp Genetic Position: Chr16, cM position of peak correlated region/allele: 9.23 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeN

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to B.burgdorferi-associated arthritis and increased arthritis severity compared to C57BL/6N. (J:73060)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73060

Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.

A novel QTL, Bbaa19, was identified in the (C57BL/6N X C3H/HeN)F1 X C57BL/6N backcross on Chr 16. Bbaa19 was linked to specific IgG levels after infection with B.burgdorferi. It mapped to 9.7.0 cM with marker D16Mit88, LRT=16.8 accounting for 11.2% variance.

[Table 2.]

C3H/HeN-derived alleles are associated with increased arthritis susceptibility and severity at all QTL mapped in this experiment.

References

• Original: J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
• All: 1 reference(s)