Tg(Alb-E2F1)8Sst
Transgene Detail

Summary

• Symbol: Tg(Alb-E2F1)8Sst
• Name: transgene insertion 8, Snorri S Thorgeirsson
• MGI ID: MGI:2429562
• Synonyms: Tg(E2F1)8Sst
• Transgene: Tg(Alb-E2F1)8Sst Location: unknown
• Alliance: Tg(Alb-E2F1)8Sst page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb-E2F1)8Sst expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  E2F1 (1869)

  E2f1	(MGI:101941)

• Mutation details: The transgene consisted of the hepatocyte-active albumin enhancer/promoter and human E2F1. Overexpression of human E2F1 was verified by Northern blot and immunhistochemical analysis of transgenic liver tissue. (J:65354)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Alb-E2F1)8Sst

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:65354 Conner EA, et al., Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis. Oncogene. 2000 Oct 19;19(44):5054-62
• All: 9 reference(s)