Eae11^SJL/J
QTL Variant Detail

Summary

• QTL variant: Eae11^SJL/J
• Name: experimental allergic encephalomyelitis susceptibility 11; SJL/J
• MGI ID: MGI:2429572
• QTL: Eae11 Location: Chr16:70561891-70562035 bp Genetic Position: Chr16, cM position of peak correlated region/allele: 40.3 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SJL/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased EAE susceptibility compared to B10.S/DvTe. (J:53193)
• Inheritance: Not Specified

Notes

Eae11 confers greater susceptibility in males than females.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53193

Analysis of 633 (SJL/J x B10.S/DvTe)F2 mice with induced experimental allergic encephalomyelitis (EAE) indicated the presence of a quantitative locus (QTL) involved with the EAE susceptibility trait. Eae11 showed maximum linkage to D16Mit140 at approximately 41 cM on mouse Chromosome 16. The authors note that this is proximal to another QTL, Eae4 placed at 26 - 50 cM. The SJL allele is associated with susceptibility. Stratification of the data by sex indicated that the effect of Eae11 on susceptibility was greater in males than in females.

J:105972

QTL associated with the modification of experimental allergic encephalomyelitis (EAE) due to non-genetic factors, such as age and time of season, were mapped in 760 (B10.S/DvTe x SJL/J)F2 intercross animals using 170 microsatellite markers (average spacing = 10 cM) in the genome scan. Animals were immunized with mouse spinal cord homogenate at an average age of 15.3 +/- 10.5 weeks of age. Animals were monitored for symptoms of EAE from 10 to 60 days post-immunization.

Linkage to EAE susceptibility in 6- to 12-week old animals and summer cohorts coincided with previously identified QTL Eae43 at 50 cM (62.26 Mb; D7Mit233) on mouse Chromosome 7 and Eae5 at 21.1 cM (38.72 Mb; D17Mit105) on mouse Chromosome 17. Eae11 at 41 cM (69.73 Mb; D16Mit140) on mouse Chromosome 16 was also detected in this cohort.

When a summer cohort of 366 F2 animals at an average age of 31 +/- 12 weeks was analyzed, significant linkage to EAE susceptibility was detected at a novel locus on mouse Chromosome 4 near D4Mit221 (58 cM),D4Mit203 (60 cM), and D4Mit204 (61.9 cM). This locus is named Eae40 (author's designation is Eae36). Eae40 maps near several previously identified autoimmune loci, such as Lbw2 (42.6 cM), Lbm1 (26.3 cM), Arvm2 (58 cM), Sles2 (58 cM), Idd9.1 (60 cM), and Idd11 (64.6 cM). Potential candidate genes identified near the Eae40 interval are Csf3r (57.5 cM), Pnrc2 (66.7 cM), and Htr1d (66 cM). Amino acid substitutions are present in Pnrc2 (L41H) and Htr1d (A22V) protein sequences between inbred strains SJL/J and C57BL/10.

References

• Original: J:53193 Butterfield RJ, et al., Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct. J Immunol. 1999 Mar 1;162(5):3096-102
• All: 2 reference(s)