Tln1^tm1Crit
Targeted Allele Detail

Summary

• Symbol: Tln1^tm1Crit
• Name: talin 1; targeted mutation 1, David R Critchley
• MGI ID: MGI:2429594
• Synonyms: Tln1^hyg, Tln1^tm2Crit, Tln^hyg
• Gene: Tln1 Location: Chr4:43531513-43562583 bp, - strand Genetic Position: Chr4, 23.05 cM
• Alliance: Tln1^tm1Crit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65873
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous locus was disrupted by the insertion of a hygromycin selection cassette. Sequences corresponding to codons 37 through 66 were replaced. (J:65873)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tln1^tm1Crit/Tln1^tm1Crit	involves: 129P2/OlaHsd * MF1

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
embryo	√
abnormal embryo development	√
abnormal gastrulation movements	√
abnormal ectoderm development	√
abnormal mesoderm development	√
embryonic growth arrest	√
decreased embryo size	√
abnormal embryonic tissue morphology	√
embryonic-extraembryonic boundary constriction	√
abnormal extraembryonic tissue morphology	√
abnormal amniotic cavity morphology	√
small amniotic cavity	√
absent ectoplacental cavity	√
absent extraembryonic coelom	√
abnormal trophoblast layer morphology	√
small proamniotic cavity	√
disorganized extraembryonic tissue	√
abnormal extraembryonic mesoderm development	√
growth/size/body	√
decreased embryo size	√
mortality/aging	√
embryonic lethality, complete penetrance	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tln1 Mutation: 146 strains or lines available

Notes

Both CGR8 and E14TG2a ES cells were injected.

References

• Original: J:65873 Monkley SJ, et al., Disruption of the talin gene arrests mouse development at the gastrulation stage. Dev Dyn. 2000 Dec;219(4):560-74
• All: 1 reference(s)