Tln1^tm1Crit
Targeted Allele Detail

Summary

• Symbol: Tln1^tm1Crit
• Name: talin 1; targeted mutation 1, David R Critchley
• MGI ID: MGI:2429594
• Synonyms: Tln1^hyg, Tln1^tm2Crit, Tln^hyg
• Gene: Tln1 Location: Chr4:43531513-43562583 bp, - strand Genetic Position: Chr4, 23.05 cM
• Alliance: Tln1^tm1Crit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65873
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous locus was disrupted by the insertion of a hygromycin selection cassette. Sequences corresponding to codons 37 through 66 were replaced. (J:65873)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tln1 Mutation: 147 strains or lines available

Notes

Both CGR8 and E14TG2a ES cells were injected.

References

• Original: J:65873 Monkley SJ, et al., Disruption of the talin gene arrests mouse development at the gastrulation stage. Dev Dyn. 2000 Dec;219(4):560-74
• All: 1 reference(s)