Tln1^tm3Crit
Targeted Allele Detail

Summary

• Symbol: Tln1^tm3Crit
• Name: talin 1; targeted mutation 3, David R Critchley
• MGI ID: MGI:2429596
• Synonyms: Tln1^neo, Tln^neo
• Gene: Tln1 Location: Chr4:43531513-43562583 bp, - strand Genetic Position: Chr4, 23.05 cM
• Alliance: Tln1^tm3Crit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65873
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous locus was disrupted by the insertion of a neomycin selection cassette. Sequences corresponding to codons 37 through 66 were replaced. (J:65873)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tln1 Mutation: 147 strains or lines available

References

• Original: J:65873 Monkley SJ, et al., Disruption of the talin gene arrests mouse development at the gastrulation stage. Dev Dyn. 2000 Dec;219(4):560-74
• All: 1 reference(s)