Tanidd3^CAST/EiJ
QTL Variant Detail

Summary

• QTL variant: Tanidd3^CAST/EiJ
• Name: TallyHo associated non-insulin dependent diabetes mellitus 3; CAST/EiJ
• MGI ID: MGI:2429608
• QTL: Tanidd3 Location: Chr16:5897590-5897739 bp Genetic Position: Chr16, cM position of peak correlated region/allele: 2.71 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: CAST/EiJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to hyperglycemia.
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:70227

Linkage analysis was performed on (C57BL/6J x TH)F1 x TH male backcross animals and (CAST/Ei x TH)F1 x TH male backcross animals to identify QTLs associated with diabetes-related phenotypes. The TH (TallyHo) strain is a mouse model for human non-insulin dependent diabetes mellitus (NIDDM). TH males develop hyperglycemia by 10-14 weeks of age whereas C57BL/6J and CAST/Ei males are normoglycemic. TH animals also exhibit increased body weight and fat pad weights compared to non-diabetic C57BL/6J and CAST/Eistrains. A locus associated with NIDDM, Tanidd1 (TallyHo associated NIDDM 1), mapped to mouse Chromosome 19 from 16 cM - 60 cM in both backcross sets (LOD = 3.1 at D19Mit103). Tanidd2 mapped to mouse Chromosome 13 from 5 cM - 70 cM in the C57BL6/J backcross (LOD = 4 at D13Mit148) and Tanidd3 mapped to mouse Chromosome 16 from 0 cM - 34 cM in the CAST/Ei backcross (LOD = 2.8 at D16Mit129). TH-derived alleles confer recessively inherited hyperglycemia at Tanidd1, Tanidd2, and Tanidd3. A QTL associated withbody weight, Tabw (TallyHo associated body weight), mapped to mouse Chromosome 7 from 0 cM - 44 cM (LOD = 3.9 at D7Mit231), and a QTL associated with fat pad weight, Tafat (TallyHo associated fat pad), mapped to mouse Chromosome 4 from 68 cM - 90 cM (LOD= 3.1 at D4Mit312). Animals homozygous for TH-derived alleles at Tafat exhibit lower fat pad weights than heterozygous animals, and animals homozygous for TH-derived alleles at Tabw exhibit lower body weights than heterozygous animals. The insulin gene, Ins1, maps near Tanidd1 and was considered as a candidate gene but sequence analysis failed to reveal differences between TH and C57BL/6J in the Ins1 promoter and coding regions.

References

• Original: J:70227 Kim JH, et al., Genetic analysis of a new mouse model for non-insulin-dependent diabetes. Genomics. 2001 Jun 15;74(3):273-86
• All: 1 reference(s)