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Afw19DBA/2
QTL Variant Detail
Summary
QTL variant: Afw19DBA/2
Name: abdominal fat weight QTL 19; DBA/2
MGI ID: MGI:2429617
QTL: Afw19  Location: unknown  Genetic Position: Chr17, Syntenic
Variant
origin
Strain of Specimen:  DBA/2
Variant
description
Allele Type:    QTL
Mutation:    Undefined
 
Mutation details

Trait Annotation
(using the Vertebrate Trait Ontology)

organism trait
body size trait
body fat mass VT:0010482
affect on abdominal fat weight - J:66233
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66233

QTL effecting body weight, obesity and muscle weight were found on mouse Chromosomes 1, 4, 5, 7, 11, 12, 13, and 17 and for leptin on 14 and insulin on chromosome 4. The cross used in the genome wide scan included approximately 400 F2 mice from a (DU6i xDBA/2)F1 intercross. DU6i is a strain selected for high body weight. 93 microsatellite markers were analyzed in the genome wide scan.

Locations of the QTL were provided by the authors and may not be equivalent to the closest microsatellites. Abdominalfat percent QTL 6 and abdominal fat weight QTL 7 were mapped to mouse chromosome 17 at positions 36 and 39 respectively.

10.03.2014 - Curator Note: We had originally associated the abdominal fat weight QTL 7 identified here, mapping to 39cM on mouse Chr 17, as Afw7. Afw7 was originally mapped using a different cross, an outbred cross of DU6 x DUK, in J:49578 in 1998. We consider the current mapping study a separate mapping experiment and have named the QTL identified here as Afw19.

References
Original:  J:66233 Brockmann GA, et al., Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice. Genome Res. 2000 Dec;10(12):1941-57
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory