Alan1^BALB/cHeA
QTL Variant Detail

Summary

• QTL variant: Alan1^BALB/cHeA
• Name: alloantigen response 1; BALB/cHeA
• MGI ID: MGI:2429622
• QTL: Alan1 Location: Chr17:4854752-46469702 bp Genetic Position: Chr17, cM position of peak correlated region/allele: 2.68 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: BALB/cHeA

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:63757

Alan1 was initially identified using Recombinant Congenic strains CcS (STS/A x BALB/cHeA). Subsequent analysis of (CcS-5 x BALB/c) F2 hybrid mice was informative to map Alan1 with mouse Chromosome 17. This locus is responsible for the proliferative response to alloantigens in mixed lymphocyte cultures (MLC). Alan1 is independent of the H2 complex and showed a significant association with D17Mit30 and D17Mit51. The Range appears to be from D17Mit19 and D17Mit138.

References

• Original: J:63757 Holan V, et al., A novel alloreactivity-controlling locus, Alan1, mapped to mouse chromosome 17. Immunogenetics. 2000 Jul;51(8-9):755-7
• All: 1 reference(s)