Pou4f2^tm1(ALPP)Whk
Targeted Allele Detail

Summary

• Symbol: Pou4f2^tm1(ALPP)Whk
• Name: POU domain, class 4, transcription factor 2; targeted mutation 1, William H Klein
• MGI ID: MGI:2429632
• Synonyms: Brn3b(AP), brn-3b^ap-ki, Pou4f2^tm1(ALPP)Kln
• Gene: Pou4f2 Location: Chr8:79159639-79163274 bp, - strand Genetic Position: Chr8, 36.99 cM, cytoband F1-F5
• Alliance: Pou4f2^tm1(ALPP)Whk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80078
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by the insertion of a construct containing human placental alkaline phosphatase (ALPP) followed by a neo cassette. (J:80078)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou4f2 Mutation: 7 strains or lines available

References

• Original: J:80078 Gan L, et al., POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification. Dev Biol. 1999 Jun 15;210(2):469-80
• All: 7 reference(s)