Ly6e^tm1Zmt
Targeted Allele Detail

Summary

• Symbol: Ly6e^tm1Zmt
• Name: lymphocyte antigen 6 family member E; targeted mutation 1, David J Zammitt
• MGI ID: MGI:2429638
• Synonyms: TSA-1^-
• Gene: Ly6e Location: Chr15:74826900-74831752 bp, + strand Genetic Position: Chr15, 34.29 cM
• Alliance: Ly6e^tm1Zmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73972
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region (exons 2 through 4) was replaced with a hygromycin selection cassette inserted by homologous recombination. Immunohistochemical analysis of the aorta at E12.5 confirmed an absence of protein expression in homozygous mutant embryos. (J:73972)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ly6e Mutation: 24 strains or lines available

References

• Original: J:73972 Zammit DJ, et al., Essential role for the lymphostromal plasma membrane Ly-6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland. Mol Cell Biol. 2002 Feb;22(3):946-52
• All: 2 reference(s)