Cp^tm1Yos
Targeted Allele Detail

Summary

• Symbol: Cp^tm1Yos
• Name: ceruloplasmin; targeted mutation 1, Kunihiro Yoshida
• MGI ID: MGI:2429641
• Synonyms: CP^-
• Gene: Cp Location: Chr3:20011218-20063309 bp, + strand Genetic Position: Chr3, 6.1 cM, cytoband D
• Alliance: Cp^tm1Yos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79916
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3' portion of exon 1 was replaced with a neomycin selection cassette. Protein was undetected by Western blot analysis of serum and liver samples obtained from homozygous mutant mice. (J:79916)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cp Mutation: 76 strains or lines available

References

• Original: J:79916 Yamamoto K, et al., Quantitative evaluation of expression of iron-metabolism genes in ceruloplasmin-deficient mice. Biochim Biophys Acta. 2002 Dec 12;1588(3):195-202
• All: 3 reference(s)