Sox9^tm2Crm
Targeted Allele Detail

Summary

• Symbol: Sox9^tm2Crm
• Name: SRY (sex determining region Y)-box 9; targeted mutation 2, Benoit de Crombrugghe
• MGI ID: MGI:2429649
• Synonyms: Sox9^c, Sox9^flox, Sox9^floxed, Sox9^loxP
• Gene: Sox9 Location: Chr11:112673050-112678586 bp, + strand Genetic Position: Chr11, 77.27 cM
• Alliance: Sox9^tm2Crm page

Skeletal image of newborn Sox9^tm2Crm/Sox9^tm2Crm H2az2^{Tg(Wnt1-cre)11Rth}/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79879
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and neomycin resistance gene cassette and a second loxP site were inserted downstream of exon 3. (J:79879)

Disease models

Expression

In Mice Carrying this Mutation:	270 assay results 11 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	45 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox9 Mutation: 33 strains or lines available

References

• Original: J:79879 Akiyama H, et al., The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 2002 Nov 1;16(21):2813-28
• All: 108 reference(s)