Gja8^Aey5
Chemically induced Allele Detail

Summary

• Symbol: Gja8^Aey5
• Name: gap junction protein, alpha 8; dominant cataract 5
• MGI ID: MGI:2429652
• Synonyms: Aey5
• Gene: Gja8 Location: Chr3:96820882-96833336 bp, - strand
• Alliance: Gja8^Aey5 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation was identifed as a T-to-C substitution at position 191 in the gene, which is predicted to cause a valine to alanine substitution at codon 64 of the encoded protein. (J:74555)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gja8 Mutation: 33 strains or lines available

References

• Original: J:74555 Graw J, et al., Characterization of a mutation in the lens-specific MP70 encoding gene of the mouse leading to a dominant cataract. Exp Eye Res. 2001 Dec;73(6):867-76
• All: 1 reference(s)