Cabin1^tm1Che
Targeted Allele Detail

Summary

• Symbol: Cabin1^tm1Che
• Name: calcineurin binding protein 1; targeted mutation 1, Jianzhu Chen
• MGI ID: MGI:2429669
• Synonyms: Cabin1-neo
• Gene: Cabin1 Location: Chr10:75481946-75600175 bp, - strand Genetic Position: Chr10, 38.56 cM
• Alliance: Cabin1^tm1Che page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72760
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The last two exons of the endogenous gene were replaced by a floxed neo cassette inserted by homologous recombination. The deleted region encoded the carboxy terminal which includes calcineurin, calmodulin, and MEF2 binding domains. (J:72760)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cabin1 Mutation: 114 strains or lines available

References

• Original: J:72760 Esau C, et al., Deletion of Calcineurin and Myocyte Enhancer Factor 2 (MEF2) Binding Domain of Cabin1 Results in Enhanced Cytokine Gene Expression in T Cells. J Exp Med. 2001 Nov 19;194(10):1449-59
• All: 1 reference(s)