Dab2^tm1Xxx
Targeted Allele Detail

Summary

• Symbol: Dab2^tm1Xxx
• Name: disabled 2, mitogen-responsive phosphoprotein; targeted mutation 1, Xiang-Xi Xu
• MGI ID: MGI:2429678
• Synonyms: dab2-
• Gene: Dab2 Location: Chr15:6329269-6470193 bp, + strand Genetic Position: Chr15, 2.15 cM, cytoband A2
• Alliance: Dab2^tm1Xxx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79862
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 2-6 with a promoter-less beta-geo cassette resulting in a fusion of the first 12 amino acids with beta-galactosidase. Reporter gene expression was not specified. (J:79862)

Expression

In Mice Carrying this Mutation:	26 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dab2 Mutation: 53 strains or lines available

References

• Original: J:79862 Yang DH, et al., Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis. Dev Biol. 2002 Nov 1;251(1):27-44
• All: 4 reference(s)