Kcnq1ot1^tm1.1Mjh
Targeted Allele Detail

Summary

• Symbol: Kcnq1ot1^tm1.1Mjh
• Name: KCNQ1 overlapping transcript 1; targeted mutation 1.1, Michael J Higgins
• MGI ID: MGI:2429679
• Synonyms: IC2KO, Kcnq1^tm1.1Mjh
• Gene: Kcnq1ot1 Location: Chr7:142766848-142850284 bp, - strand Genetic Position: Chr7, 88.15 cM
• Alliance: Kcnq1ot1^tm1.1Mjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79882
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is derived from Kcnq1^tm1Mjh. The floxed PGK-neo cassette that replaced the two floxed CpG islands of intron 10 (KvDMR1) was deleted by crossing mutant animals to the cre deleter strain TgN(Zp3-cre)3Mrt. (J:79882)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnq1ot1 Mutation: 0 strains or lines available

References

• Original: J:79882 Fitzpatrick GV, et al., Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. Nat Genet. 2002 Nov;32(3):426-31
• All: 7 reference(s)