Chl1^tm1Mtg
Targeted Allele Detail

Summary

• Symbol: Chl1^tm1Mtg
• Name: cell adhesion molecule L1-like; targeted mutation 1, Dirk Montag
• MGI ID: MGI:2429688
• Synonyms: Chl1^-, CHL1-deficient
• Gene: Chl1 Location: Chr6:103487372-103709999 bp, + strand Genetic Position: Chr6, 47.97 cM, cytoband E1
• Alliance: Chl1^tm1Mtg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79902
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 (and 4 kb of intron 1) with a PGK-neo cassette via homologous recombination, thus deleting the ribosomal binding site, translation initiation codon, and signal sequence. Absence of gene expression in homozygous mutant animals was verified by Western blot analysis of brain protein extracts. (J:79902)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chl1 Mutation: 57 strains or lines available

References

• Original: J:79902 Montag-Sallaz M, et al., Misguided axonal projections, neural cell adhesion molecule 180 mRNA upregulation, and altered behavior in mice deficient for the close homolog of L1. Mol Cell Biol. 2002 Nov;22(22):7967-81
• All: 32 reference(s)