Asic3^tm1Wsh
Targeted Allele Detail

Summary

• Symbol: Asic3^tm1Wsh
• Name: acid-sensing ion channel 3; targeted mutation 1, Michael J Welsh
• MGI ID: MGI:2429689
• Synonyms: ASIC3-, DRASIC-
• Gene: Asic3 Location: Chr5:24618449-24622836 bp, + strand Genetic Position: Chr5, 11.72 cM
• Alliance: Asic3^tm1Wsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73505
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a floxed neomycin selection cassette inserted by homologous recombination. The deleted region contained the translational start codon and encoded the transmembrane domain and a portion of the extracellular domain. Transcript was undetected in homozygous mutant mice by RT-PCR analysis. (J:73505)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Asic3 Mutation: 30 strains or lines available

References

• Original: J:73505 Price MP, et al., The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice. Neuron. 2001 Dec 20;32(6):1071-83
• All: 21 reference(s)