Brca2^tm2Mak
Targeted Allele Detail

Summary

• Symbol: Brca2^tm2Mak
• Name: breast cancer 2, early onset; targeted mutation 2, Tak W Mak
• MGI ID: MGI:2429691
• Synonyms: Brca2 fl9-10
• Gene: Brca2 Location: Chr5:150446095-150493794 bp, + strand Genetic Position: Chr5, 89.52 cM
• Alliance: Brca2^tm2Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79697
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 9 and 10 were left flanked by single loxP sites after a floxed hygromycin selection cassette was excised from intron 8 by in vitro cre mediated recombination. (J:79697)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brca2 Mutation: 132 strains or lines available

References

• Original: J:79697 Cheung AM, et al., Loss of Brca2 and p53 Synergistically Promotes Genomic Instability and Deregulation of T-cell Apoptosis. Cancer Res. 2002 Nov 1;62(21):6194-204
• All: 4 reference(s)