Brca1^tm2Mak
Targeted Allele Detail

Summary

• Symbol: Brca1^tm2Mak
• Name: breast cancer 1, early onset; targeted mutation 2, Tak W Mak
• MGI ID: MGI:2429692
• Synonyms: Brca1^fl5-6
• Gene: Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
• Alliance: Brca1^tm2Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63282
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 5 and 6 were left flanked by single loxP sites after a floxed hygromycin selection cassette was removed via in vitro cre mediated recombination. (J:63282)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca1^tm2Mak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brca1 Mutation: 114 strains or lines available

References

• Original: J:63282 Mak TW, et al., Brcal required for T cell lineage development but not TCR loci rearrangement. Nat Immunol. 2000 Jul;1(1):77-82
• All: 3 reference(s)