Arx^tm1Kki
Targeted Allele Detail

Summary

• Symbol: Arx^tm1Kki
• Name: aristaless related homeobox; targeted mutation 1, Kunio Kitamura
• MGI ID: MGI:2429693
• Synonyms: Arx^X*
• Gene: Arx Location: ChrX:92330113-92341963 bp, + strand Genetic Position: ChrX, 41.05 cM
• Alliance: Arx^tm1Kki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79871
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a STOP-IRES-lacZ-neo cassette into exon 2, which encodes a homeobox domain. (J:79871)

Disease models

Expression

In Structures Affected by this Mutation:

21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Arx Mutation: 20 strains or lines available

References

• Original: J:79871 Kitamura K, et al., Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans. Nat Genet. 2002 Nov;32(3):359-69
• All: 6 reference(s)