Cacnb2^tm1Rgg
Targeted Allele Detail

Summary

• Symbol: Cacnb2^tm1Rgg
• Name: calcium channel, voltage-dependent, beta 2 subunit; targeted mutation 1, Ronald G Gregg
• MGI ID: MGI:2429694
• Synonyms: beta2-null, Cavbeta2^-
• Gene: Cacnb2 Location: Chr2:14607899-14992719 bp, + strand Genetic Position: Chr2, 10.7 cM
• Alliance: Cacnb2^tm1Rgg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80080
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The gene was disrupted by replacement of exons 4-13 with a PGK-neo cassette. (J:80080)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacnb2 Mutation: 50 strains or lines available

References

• Original: J:80080 Ball SL, et al., Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Invest Ophthalmol Vis Sci. 2002 May;43(5):1595-603
• All: 6 reference(s)