Pou3f2^tm1Tno
Targeted Allele Detail

Summary

• Symbol: Pou3f2^tm1Tno
• Name: POU domain, class 3, transcription factor 2; targeted mutation 1, Tetsuo Noda
• MGI ID: MGI:2429695
• Synonyms: Brn-2^DeltaC
• Gene: Pou3f2 Location: Chr4:22482780-22488366 bp, - strand Genetic Position: Chr4, 9.73 cM
• Alliance: Pou3f2^tm1Tno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30429
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3' portion of the endogenous gene encoding both the POU specific and POU homeo domains was replaced by a PGK-neo cassette inserted by homologous recombination. The loss of octamer binding activity in homozygous mutant mice was demonstrated with electrophoresis mobility shift assays. (J:30429)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou3f2 Mutation: 19 strains or lines available

References

• Original: J:30429 Nakai S, et al., The POU domain transcription factor Brn-2 is required for the determination of specific neuronal lineages in the hypothalamus of the mouse. Genes Dev. 1995 Dec 15;9(24):3109-21
• All: 3 reference(s)