Tg(SERPINA1-BCL2)1Pva
Transgene Detail

Summary

• Symbol: Tg(SERPINA1-BCL2)1Pva
• Name: transgene insertion 1, Pierre Vassalli
• MGI ID: MGI:2429696
• Synonyms: ATT-Bcl2
• Transgene: Tg(SERPINA1-BCL2)1Pva Location: unknown
• Alliance: Tg(SERPINA1-BCL2)1Pva page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(SERPINA1-BCL2)1Pva expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2 (596)

  Bcl2	(MGI:88138)

• Mutation details: The human SERPINA1 promoter was used to drive expression of human BCL2. Three lines were generated with greater than 10 copies of the transgene in 2 lines and greater than 30 copies of the transgene in one line. The line with greater than 30 copies of the transgene was used. (J:32092)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:32092 Rodriguez I, et al., A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection. J Exp Med. 1996 Mar 1;183(3):1031-6
• All: 2 reference(s)