Dps3^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Dps3^DBA/2J
• Name: delta power in slow-wave sleep 3; DBA/2J
• MGI ID: MGI:2429722
• QTL: Dps3 Location: Chr17:33819721-36250180 bp Genetic Position: Chr17, cM position of peak correlated region/allele: 17.98 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68838

The authors indicated that short-wave sleep in mice can be measured by EEG activity within the 1-4 Hz range or delta power. Sleep loss results in an increase in delta power whereas excess sleep causes a decrease in delta power. The differences in delta power could be measured as a QTL in 25 strains within the BXD/Ty recombinant inbred line. QTL Dps3 was found on mouse Chromosome 17 with the closest linked markers identified as D17Mit16 , D17Mit28 and D17Mit233 with a LOD score of 3.17. The suggestive range was from 16.6 - 22.9 cM.

References

• Original: J:68838 Franken P, et al., The homeostatic regulation of sleep need is under genetic control. J Neurosci. 2001 Apr 15;21(8):2610-21
• All: 1 reference(s)