Etmr^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Etmr^DBA/2J
• Name: ethanol metabolism rate; DBA/2J
• MGI ID: MGI:2429725
• QTL: Etmr Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:76704

25 BXD (C57BL/6J x DBA/2J) recombinant inbred (RI) strains were screened for loci associated with blood ethanol concentration (BEC) and ethanol metabolism after IP ethanol administration. Parental strain C57BL/6J exhibits 10-15% slower elimination of blood alcohol compared to parental strain DBA/2J.

A locus mapping to 6.27 cM on mouse Chromosome 17, Etmr, reached statistical significance (P<0.001) in linkage with ethanol metabolism rate. Etmr has a QTL range of 3 cM - 20 cM on chromosome 17. A possiblecandidate gene for Etmr is Sod2.

References

• Original: J:76704 Grisel JE, et al., Mapping of Quantitative Trait Loci Underlying Ethanol Metabolism in BXD Recombinant Inbred Mouse Strains. Alcohol Clin Exp Res. 2002 May;26(5):610-6
• All: 1 reference(s)