Eye2^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Eye2^DBA/2J
• Name: eye weight 2; DBA/2J
• MGI ID: MGI:2429729
• QTL: Eye2 Location: Chr17:26505337-41105037 bp Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased eye weight compared to C57BL/6J. (J:53890)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

This allele exhibits partial dominance for increased eye weight.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:53890

Eye weight differs significantly between inbred strains C57BL/6J and DBA/2J. Eye weight was measured in the 26 strains in the BXD (C57BL/6J x DBA/2J) RI line. A major locus (Eye1) was found to map to mouse Chromosome 5. A QTL with a lesser effect (Eye2) was seen on mouse Chromosome 17 between Hba-ps4 and Crisp2. Phenotypic analysis of F2 mice derived from (C57BL/6J x DBA/2J) mice verified the Chromosome 17 location of Eye2 specifically to a region on mouse Chromosome 17 between 10 cM and 16 cM.

References

• Original: J:53890 Zhou G, et al., Eye1 and Eye2: gene loci that modulate eye size, lens weight, and retinal area in the mouse. Invest Ophthalmol Vis Sci. 1999 Apr;40(5):817-25
• All: 1 reference(s)