Summary |
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Variant origin |
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Variant description |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:52511Human porphyrias can be modelled in iron-loaded mice exposed to hexachlorobenzene. C57BL/10ScSn is a protoytpe susceptible strain whereas DBA/2 mice are extremely resistant. A search for susceptibility loci was undertaken using QTL analysis with microsatellite markers of high and low responders from an F2 intercross. Susceptibility is defined as the accumulation of uroporphrin in the liver. Statistical analysis revealed the presence of a region on mouse Chromosome 17 between D17Mit49 and D17Mit24 associated with porphyria susceptibility (LOD = 3.6). This locus was assigned the symbol Hcbip2. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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