Il2rg^tm1Sug
Targeted Allele Detail

Summary

• Symbol: Il2rg^tm1Sug
• Name: interleukin 2 receptor, gamma chain; targeted mutation 1, Kazuo Sugamura
• MGI ID: MGI:2429736
• Synonyms: CDgamma-
• Gene: Il2rg Location: ChrX:100307991-100311861 bp, - strand Genetic Position: ChrX, 43.9 cM
• Alliance: Il2rg^tm1Sug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31167
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A sequence fragment containing portions of exon 7 and 8 was replaced with a neo cassette inserted by homologous recombination. The deleted region encoded the majority of the SH2-like domain. Flow cytometry and the use of labeled thymidine indicated that the mutant protein localized to the surface of thymocytes but did not transduce signals. (J:31167)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Il2rg^tm1Sug

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Il2rg Mutation: 179 strains or lines available

Notes

ES cell line = E14.1 (129P2/OlaHsd) or EK.CCE (129S/SvEv-Gpi1^c).

References

• Original: J:31167 Ohbo K, et al., Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain. Blood. 1996 Feb 1;87(3):956-67
• All: 58 reference(s)