Tg(Ttr-Cdkn1a)36Tvd
Transgene Detail

Summary

• Symbol: Tg(Ttr-Cdkn1a)36Tvd
• Name: transgene insertion 36, Terry Van Dyke
• MGI ID: MGI:2429747
• Transgene: Tg(Ttr-Cdkn1a)36Tvd Location: unknown
• Alliance: Tg(Ttr-Cdkn1a)36Tvd page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ttr-Cdkn1a)36Tvd expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cdkn1a (MGI:104556)

• Mutation details: The transgenic construct contained murine Cdkn1a cDNA sequence adjoined to murine transthyretin (Ttr) sequence including 3 kb of the upstream regulatory region, exon 1, intron 1, and a portion of exon 2. Both the endogenous start codon and an additional ATG in exon 2 of Ttr were converted to restriction sites by site-directed mutagenesis. The Ttr regulatory region directs expression in the liver. (J:31291)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:31291 Wu H, et al., Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration. Genes Dev. 1996 Feb 1;10(3):245-60
• All: 2 reference(s)