Ryr3^tm1Tno
Targeted Allele Detail

Summary

• Symbol: Ryr3^tm1Tno
• Name: ryanodine receptor 3; targeted mutation 1, Tetsuo Noda
• MGI ID: MGI:2429752
• Gene: Ryr3 Location: Chr2:112461700-113047441 bp, - strand Genetic Position: Chr2, 57.2 cM, cytoband E5-F3
• Alliance: Ryr3^tm1Tno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34908
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. No protein was detected by Western blot analysis of brain tissue obtained from homozygous mutant mice. (J:34908)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Ryr3^tm1Tno/Ryr3^tm1Tno	involves: 129S4/SvJae
hm2	Ryr3^tm1Tno/Ryr3^tm1Tno	involves: 129S4/SvJae * C57BL/6N
ht3	Ryr3^tm1Tno/Ryr3^+	involves: 129S4/SvJae * C57BL/6N

Phenotypes:

Affected Systems	hm1	hm2	ht3
show or hide all annotated terms
behavior/neurological	√	√	√
impaired passive avoidance behavior		√	√
abnormal contextual conditioning behavior		√	√
abnormal spatial learning		√	√
hyperactivity	√
increased locomotor activity	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ryr3 Mutation: 261 strains or lines available

References

• Original: J:34908 Takeshima H, et al., Generation and characterization of mutant mice lacking ryanodine receptor type 3. J Biol Chem. 1996 Aug 16;271(33):19649-52
• All: 13 reference(s)